According to the American Heart Association it is currently estimated that 59,700,000 Americans have one or more types of cardiovascular disease(CD). Of these, more than 2600 die per day; an average of every thirty 33 seconds. Current therapy usually addresses treatment, not prevention. Modern medicine (based primarily on pharmaceutical drugs and surgery) has failed to halt the spread of CD. From 1979 to 1997, the number of Americans discharged from short-stay hospitals with cardiovascular disease as the first listed condition of their diagnosis has increased by over 25%.
Ongoing Medical Research on the uses of Pyruvate provides reason to believe that both prevention and better treatment of CD will become available.
The American Heart Association, and major universities, and cardiovascular clinics throughout the United States and Canada are publishing such research.The Internet provides easy access to CD research being conducted in conjunction with Pyruvate. Refer to technical articles posted on the main home page of our company’s web-site at www.coenzyme-a.com under article titled: Circulation, and Cardiovascular Research.
When properly introduced into the human body, Pyruvate acts as a source of myocardial energy metabolism.The Evolutionary Origin of Cellular MetabolismThis creates a number of cellular actions that can benefit the human heart. style='mso-spacerun:yes'> Such modulation of the myocardial metabolism provides a new approach to improving the performance of a healthy or dysfunctional heart.
Hearts use a variety of energy substrates. The majority of the heart’s energy requirements are provided by acetyl coenzyme-A’s oxidation of fatty acids and carbohydrates. Lack of acetyl coenzyme-A can reduce fatty acid oxidation. As a result, the energy production in hypertrophied and failing hearts becomes more dependent on the metabolism of carbohydrates such as glucose. The above mentioned research has shown that Pyruvate could provide a much more beneficial source of energy to healthy or diseased hearts than the metabolism of carbohydrates such as glucose.
To be beneficial to the healthy or diseased heart (and other organs), Pyruvate must enter the systemic blood stream intact, targeting different cells in such organs as the heart, liver, and brain. Further, it must penetrate the inner mitochondria membrane barrier and enter the cells in order to exert its- antioxidant and energy metabolism benefits. Unfortunately, without complex chemical modification, Pyruvate orally ingested as a dietary supplement provides very little benefit to a healthy or diseased heart or other organs of the body because it can’t effectively penetrate into the cells of the body. Further Pyruvate dietary supplements are stabilized in a salt base. Long term ingestion may result in high blood pressure or side effects of nausea, or gastric intestinal upset.
At the University of North Texas, Cardiovascular Research Institute, Health and Science Division, a chemically modified form of Pyruvate has been tested. It has been successfully applied in the medical treatment of such serious diseases as diabetes, obesity and heart failure. Refer to Cardiovascular Research Institute at “http://www.hsc.unt.edu/research/ifd/documents/DIET.htm”.
According to the large body of supporting CD medical research information, the medical claims of the above mentioned Cardiovascular Research Institute seem to be well supported. Their claims are based on their research and investigation of their specific development, which chemically Hydrogen bonds Pyruvate with an Amino Acid conjugation. The reported medical results as follows:
“The beneficial effects on the human body, including metabolic protection of the heart, the reduction of fatty tissue, while possibly increasing lean body mass, antioxidant protection, and the augmentation of insulin in better controlling the blood sugar levels”.
Coenzyme-A Technologies Inc. commercially introduced its nutraceutical Coenzyme-A product over five years ago. Coenzyme-A TM nutraceutical product embodies a complete endogenous synthesis of a Pyruvate Dehydrogenase complexCoenzyme-A, Pyruvate Dehydrogenase (PDH) and the TCA Cycle, and Acyl Carrier Proteins complex that enables these complexes to penetrate the inner mitochondria membrane barrier and enter the cells to exert their antioxidant and energy metabolism benefits.
Coenzyme-A TM effectively delivers Pyruvate into the cells of the body! The Structural and Biochemical Functions of Coenzyme-ATM Since its introduction, Coenzyme-A Technologies Inc. has received customer reports and testimonials about Coenzyme-A’s benefits pertaining to various cardiovascular diseaseTestimonials for Coenzyme ATM conditions. The above mentioned research substantiates the testimonial information that our customers have been providing.
The additional nutraceutical benefits that can be derived from taking Coenzyme-A are already well documented. These can be briefly summarized as follows:
The success of Coenzyme-A TM lies in the fact that it delivers effective natural nutraceutical components not only into the cells of the body, but even more crucial through the inner mitochondrial membrane barrier of the human cell itself.