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The Importance of Coenzyme-A in Perimenopausal and Menopausal Women
Research shows that hormonal changes and chemical imbalances in perimenopausal
and menopausal women contributes to higher levels of cholesterol, increased
fat storage, acne, stress, anxiety and depression.
Cardiovascular diseases are the main cause of death in men and women. Their
incidence, rapidly growing in the perimenopausal and menopausal period, is
related to increased levels of cholesterol and triglycerides.
The body has a natural tendency to store away any excess calorie intake in
its fat depot, this natural tendency increases in perimenopausal and menopausal
women. Coenzyme-A is the key that unlocks this fat depot and is the agent
that converts the stored fat into energy through lipid metabolism, which
reduces cholesterol and triglycerides by increasing fat utilization.
The cumulative effects of 30 years or so of reproductive cycles reduces the
availability of Coenzyme-A from the body's total Coenzyme-A pool. Each
reproductive cycle depletes some Coenzyme-A from a resource that is very
often deficient from the start. Added to this is pregnancy and nutritional
deficiencies. Both of these deplete even more Coenzyme-A, allowing the deficiency
to become even more severe. This is why many women gain a significant amount
of weight after having children and also when they are perimenopausal and
menopausal. Their Coenzyme-A pool is dwindling.
Studies also show that Coenzyme-A plays a major role in the body's ability
to cope with stress, anxiety, and depression and strengthen the immune system.
In combating stress and anxiety, the body secretes hormones as a means to
adapt to stress. These hormones are derivatives of cholesterol and an increased
demand for them will draw on the available Coenzyme-A. Lipid (fat) metabolism
and energy production may therefore be compromised, rendering the body more
prone to depleted energy, weight gain, acne, cardiovascular diseases, cancer
and other diseases.
References:
1. Binaghi P, Cellina G, Lo Cicero G, et al. Evaluation of the
cholesterol-lowering effectiveness of pantethine in women in perimenopausal
age. Minerva Med 1990;81:475-479
2. Leung, L. H., M.D.; Pantothenic Acid as a Weight Reducing Agent: Fasting
Without Hunger, Weakness and Ketosis; Medical Hypothesis 1995; 44, 403, 405.
3. Robishaw, J. D. & Neely, J. R.; Coenzyme A Metabolism; American Journal
of Physiology 1985; 248: El- E9.
4. Abiko Y.; Metabolism of Coenzyme-A; New York Academic Press, Third Edition
1975; 7:1-25.
5. Krebs, H. A.; The Regulation of Release of Ketone Bodies By the Liver;
Advanced Enzyme Reaction 1966; 4: 339-354.
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