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SKIN MATRIXTMAgeing Inhibitor

by Nickolaos D. Skouras, Ph.D.


Introduction

NEWLY DEVELOPED BIOLOGICALLY ACTIVE MATRIX ELEMENTS IN ANTI-AGING SKIN PRODUCTS! "PIONEER IN NATURAL SKIN CARE" "Redefining the skins aging, and cellular rejuvenation process"

SKIN MATRIXTM is the most innovative skin rejuvenating product in the industry today. Its uniqueness is derived from the functional properties of its own individual ingredients, in which upon blending, undergo certain chemical bonding reactions, thus creating a new molecular structure.

The benefits of SKIN MATRIX TM include:

• Helps Prevent the formation of wrinkles and sagging skin.
• Protects against oxidation mechanisms.
• Diminishes the appearance of wrinkles while inhibiting the formation of new ones.
• Essential for DNA protection against skin degeneration.
• Protects the skin cells from extreme environmental conditions and dehydration.
• Restores tissue by increasing cellular turnover.
• Reduces allergic type inflammation.
• Repairs damaged capillaries that are dilated.
• Maintains a natural balance of the skin's immune system.
• Provides all the antioxidant protection derived from plant protective mechanisms.
• Protects and repairs the skin from solar radiation.
• P.H. balanced to the natural P.H. of human skin.

COENZYME-A TECHNOLOGIES INC. introduces a series of proprietary Cosmeceutical products that were developed according to the most recent anti aging research. These products not only address nutritional deficiencies and environmental stress from pollution (biologically persistent ubiquitous toxins), but also the Non Enzymatic Glycosylation or Maillard Reaction. This is the spontaneous chemical reaction that begins when sugar glucose attaches to skin collagen and eventually ends in the irreversible cross- linking of collagen molecules. Extensive non- enzymatic cross-linking makes collagen less susceptible to the remodeling mechanisms that correct the cross- linking process. The cross -linking of collagen reduces skin elasticity, which is visually seen as skin wrinkles. It also contributes to other visual signs of skins aging such as yellowing of the skin and age spots. Anti aging skin care products that use antioxidants and vitamins to scavenge free -radicals only act indirectly to inhibit skin aging. Antioxidants and vitamins do nothing to inhibit the underlying cause of skin aging, which is the cross-linking of collagen molecules. Free-radicals do exacerbate the aging of skin. But, even if every free-radical were scavenged by antioxidants or vitamins, collagen cross- linking that forms wrinkles would continue unabated.

The following information consisting of the answer, to the most frequently asked question regarding the SKIN MATRIXTM products.

Why does my face get red hot, and irritated when I use the SKIN MATRIXTM spray? Answer: Regarding the irritation that some of you might experience when first using our skin products, we feel that we have a very logical, (or biological) explanation for that reaction. Aside from the anti-ageing, and rejuvenating skin properties that the SKIN MATRIXTM displays it was also designed to prevent and repair the Homeostatic mechanisms of the human epidermal cells Using our own personal non invasive skin care protocol, let's begin with the SKIN MATRIXTM foaming Cleanser, as the recommended usage two times daily (for best results leave on for two to three minutes before thoroughly rinsing.) It will not only properly deep cleanse, and exfoliate your skin, but in conjunction with the SKIN MATRIXTM spray, it will further diminish fine lines, skin discoloration's, and light blemishes literally upon its first usage. And yet another very important factor is that it will further stimulate cellular turnover, while further being that it is also pH. balanced at 4.9 (that of healthy human skin's, Acid Mantle Barrier) it will not disturb the users skin natural biological protective Acid Mantle Barrier properties. Other benefit's of using the SKIN MATRIXTM product's, is to essentially protect the skin's cellular DNA. from nuclear fragmentation which results not only from the exposure to the environmental elements, and cytotoxic agents that will further accelerate the skins aging process. Coincidentally as it is very well know amongst the scientific community, one of the consequences of DNA. damage repair is Polly (ADP-Ribose) Polymerase enzyme (PARP)- catalyzed destruction of the active form of Niacin, NAD and the generation of free ADP-Ribose in chromatin. And yet another consequence of UV radiation (and I should really know, considering all the self induced sun damage that I have caused myself all my life from being a sun worshiper!) and metabolism in general is the formation of reactive carbonyl species(carbonylation of proteins) that ultimately leads to the formation of AGE. A major focus of SKIN MATRXTM technology is on the inherent ability of human skin cells to repair damage to their DNA. Published pre-clinical research has shown that repair of DNA. damage requires the active form of the vitamin Niacin, Nicotinamide Adenine Dinucleotide (NAD.) This research further shows that a large portion of our population does not have optimal levels of NAD. in their skin's cells. Therefore we can conclude that DNA. repair can be optimized by the elevation of skin cell NAD. content. Since NAD. is also very important for energy metabolism, by optimizing NAD content, it also enhances the energy metabolism in human skin cells. Our technology is based on the creation of bioactive ingredients that can be effectively delivered (Active Transport SystemTM )to the skin cells, unlike the vitamin precursor ingredients used by other nutraceutical, / cosmeceutical companies that can not enter the skin cells due to structural constraints, and limitations and will not be effectively be retained in skin following topical application. The irritation effect that you might experience at first is basically the flushing effect of the Niacin as it penetrates deep into the dermis and eventually enters the blood stream. This effect will dissipate upon continuous usage of the product. Given the active biological composition of the SKIN MATRIXTM, it will further act as a potent radio-protective agent against all forms of irradiation (solar, microwave, electrical currents, such as computers, and especially ionizing radiation), which inturn is trapped and ubiquitous stored in the epidermal protective layer of the human skin. Thus we have yet another logical, (or biological) explanation of the possible irritating, or flushing effect that most of us experience when first using the SKIN MATRIXTM which is not only the Hemo vaso-dilation, and circulatory effect's, but also the detoxification effect that has now been initiated by it, and which upon continuos usage will eventually decrease. As soon as the skin normalizes it's Homeostasis it will eventually fully dissipate.

SKIN MATRIX "Aging Inhibitor"

BENEFITS INCLUDE:

  • Diminishing the appearance of wrinkles while inhibiting the formation of new ones, thus breaking the vicious cycle of collagen cross-linking that accelerates skin aging. This is done by preventing the formation of AGEs by inhibiting the onset of Non Enzymatic Glycosylation while maintaining control of Glycolysis. This Acts as stabilizer of cellular structures under extreme environmental conditions, while protecting biological membranes, and enzymes under conditions of dehydration, elevated temperatures oxidation and lipid peroxidation.
  • Protection against the transitional metal ions (copper and iron found in vitamin C - serums) that result in the formation of insoluble collagen aggregates. This reaction is then mediated by hydrogen peroxide which than generates hydroxyl radicals scientifically known as the Fenton reaction. Hydroxyl radical attack is known to lead to cross-linking, which is further enhanced by glycated proteins resulting in alteration of collagen properties and accelerated aging of the skin.
  • Essential for D N A protection against degradation and protein scission activities in the presence of Ascorbic acid, when combined with the ions of copper or iron. These are the two most common transitional metals that exhibit these destructive activities. Amongst the various reducing agents that lead to collagen cross- linking Ascorbate was the most effective in causing protein cleavage and D N A scission in its reduced or oxidized state.

  • Inhibits the negative effects of Ascorbic Acid induced free radical formation and ascorbate induced (apoptoticcell death) characterized by cell shrinkage, nuclear fragmentation and internucleosomal D N A cleavage in human cells accelerating the skin's aging process.

  • Allows antioxidants and specific growth factors (involved in fiberoblast growth and the production of connective tissue) to penetrate through the stratum corneum barier and into the living layer in the epidermis. While providing (sacrificial targets for cross-linking reactions) these are important because they "take the heat from free radicals, allowing protein molecules to continue to function.

  • Promotes and aids in the enhanced regulation of (Sir2p) which have been scientifically discovered to inhibit the aging process by the mechanism of the (silencing of the genes). The specific genes that are implicated in this deadly process one being the ring shaped "destroyer" D N A fragments that, in the aging process proliferate inside cells, to the point of cell strangulation and cell death. These fragments are called: (EXTRACHROMOSOMAL r D N A CIRCLES, or ERCs). By joining forces with the (Sir2)"silent information regulator" it protects skin cells from APOPTOSIS, a kind of programmed cell death (cellular suicide) that can be induced by cytotoxic substances such as bile salts and other environmental ubiquitous toxic effects of pollution.

  • Essential for full acquisition of thermotolerance in aging skin, and aids in accelerating hydrophobic attraction and molecular binding which is a very important part of the skins protective mechanism in preventing glycation and structural modification of proteins.
  • Preventing the effects of non-enzymatic glycosylation in structural and connective tissues in the stratum corneum. Glucose binding to keratin and proteins of the insoluble stratum corneum which serve as a Stable parameter in the development of dermatological complications related to the browning discoloration and pigmentation of the aging skin.

  • The restoration of tissue integrity by increasing the granulation of tissues resulting in the increased synthesis of the connective tissue matrix. Collagen is the major protein of the extra cellular matrix, and is the component that ultimately contributes to wound healing strength and recovery.

  • Essential in preserving and improving significantly higher stimulation of (C -Peptide secretion) beta cell function protecting them from end- stage destruction.
  • SKIN MATRIX TM Active ingredients:

    C-MATRIXTM, L-Ascorbic acid (non transitional), GLYCO-MATRIXTM Consisting of Monosaccharides, Disaccharides, Ionic Polysaccharides, Polysulfated Glycosaminoglycans and Polyols (all non reducing sugars),
    XYLAN Pentose Monosaccarides
    TREHALOSE
    ARABINOGALACTAN (Siberian Larch tree)
    BIS (MALTOLATO) Oxovanadium IV (BMVO)
    ORTHOSILICIC ACID

    All of Natural Food Origin
    All FDA approved under: GRASS STATUS

    ANTIOXIDANTS
    L-Alanine
    Ascorbic Acid
    Nicotinic Acid
    Nicotinamide
    AMINO COATTM (TMG. a Natural Metabolic Intermediate, and Methyl donor)
    PHYTO ANTIOXIDANTS:
    Citrus Paradisi (standardized extract)
    SYNYRGIZED CAMU- CAMUTM, Vitamin C from organic whole food sources
    Rutin (97.53% Standardized Extract)
    Taxifolin-DIHYDROQUERCETIN (97.5% Standardized Extact, -Vitamin P)
    Blueberry Leaf Extract (20% S.-E.)
    Green Tea Extract (95% S.-E.)
    Parilla Seed Extract (20% S.-E.)
    Centella Asiatica Extract (20%S.-E.)
    Sodium Glycerophosphate
    CERAMIDE P-C (Phyto-origin),
    Other Ingredients, Distilled Water, Vegetable Glycerine

    Shake well before using.
    For best results REFRIGERATE, or store in a cool environment.

    Special Notice: The statements contained in this article have not been evaluated by the U.S. Food & Drug Administration (FDA). The products discussed are not intended to diagnose, treat, cure, or prevent any disease.


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